Description

Precision Filling, Reliable Stoppering & Secure Sealing

Our Vial Filling, Stoppering & Sealing Systems are designed for accurate liquid filling, reliable rubber stopper placement, and secure aluminium sealing of pharmaceutical vials. Available in linear and rotary configurations, these systems support aseptic processing with automated operation, precise filling control, and integrated in-process monitoring.

The equipment can be configured with rotary piston or peristaltic filling pumps, semi or full stoppering mechanisms, in-line weighing systems, and aluminium sealing arrangements to meet specific production requirements.

Filling

Precision Filling with In-Line Weight Verification

The filling system is designed to deliver accurate and consistent dosing of liquid pharmaceutical products into vials.

  • Servo-controlled filling for precise and repeatable dosing.

  • High Filling accuracy depending on product characteristics and system configuration.

  • Integrated in-line weighing for filling accuracy verification.

  • Automatic filling volume adjustment based on configured parameters.

  • No Vial – No Fill functionality to minimize product wastage.

  • Suitable for different vial sizes and filling volumes.

  • Supports 100% In-Process Control (IPC) or statistical sampling-based IPC.

Filling Pump Technologies
Rotary Piston Pumps & Peristaltic Pumps

The system offers two filling pump technologies based on product characteristics and process requirements.

Rotary Piston Filling Pumps
  • Volumetric filling with accurate and repeatable dosing.

  • Servo-controlled piston movement for filling volume adjustment.

  • Suitable for a wide range of liquid pharmaceutical formulations.

  • Designed for consistent filling performance at high production speeds.

Peristaltic Filling Pumps
  • Gentle filling through controlled compression of flexible tubing.

  • Product-contact flow path limited primarily to the tubing and associated components.

  • Suitable for sensitive pharmaceutical formulations.

  • Supports quick product changeover and reduced cleaning requirements.

In-Line Weighing System

100% Weight Verification & Automatic Rejection

The in-line weighing system provides real-time monitoring of vial filling accuracy through automated weight measurement.

  • Pre-fill and post-fill weighing for net fill-weight calculation.

  • 100% in-process weight verification or statistical IPC options.

  • Automatic identification of underfilled and overfilled vials.

  • Automatic rejection of vials outside configured weight limits.

  • Filling weight monitoring and recording for batch documentation.

  • Feedback-based filling adjustment, where configured, to maintain consistent dosing.

  • Integration with the machine control system for monitoring and reporting.

Stoppering

Stoppering System
Semi-Stoppering & Full-Stoppering Solutions

The stoppering system is designed for accurate positioning and insertion of rubber stoppers into filled vials.

Semi-Stoppering
  • Partial insertion of rubber stoppers into filled vials.

  • Suitable for vials intended for subsequent lyophilization.

  • Maintains the required stopper position during transfer to the lyophilizer.

  • Controlled stopper placement for consistent operation.

Full-Stoppering
  • Complete insertion of rubber stoppers into filled vials.

  • Suitable for liquid injectable products.

  • Automated stopper feeding, orientation, and placement.

  • Stopper presence detection and rejection options.

  • Consistent stopper insertion to support container closure integrity.

Sealing

Aluminium Sealing System

Secure Sealing for Pharmaceutical Vials

The sealing system is designed to apply aluminium caps to fully stoppered vials, providing secure closure for pharmaceutical packaging.

  • Automated aluminium cap feeding and placement.

  • Controlled crimping for consistent sealing.

  • Suitable for different vial and aluminium cap sizes.

  • Cap presence detection and rejection options.

  • Adjustable sealing parameters based on container specifications.

  • Integrated sealing operation for continuous vial processing.

Technical specifications

Precision Filling Filling accuracy with in-line weighing
Advanced Filling Pump Rotary piston and peristaltic pumps
Reliable Stoppering Semi-stoppering and full stoppering
Aluminum Sealing Cap placement and controlled crimping
Inline Weighing & IPC 100% weight verification, monitoring and rejection

Key features

  • High-Speed Performance: Production capacity of up to 400 vials/min.
  • Flexible Configurations: Available in linear and rotary machine designs.
  • Advanced Aseptic Protection: Compatible with oRABS, cRABS, and isolator systems.
  • Fully Servo-Controlled Operations: Ensures precise synchronization and consistent machine performance.